*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OH4725820
CHEMICAL NAME           : Leucomycin V, 3-acetate 4(sup B)-(3-methylbutanoate),
                          (2R-cis)-(3-methyloxiranyl) phosphonate (1:1)
CAS REGISTRY NUMBER     : 96740-84-0
LAST UPDATED            : 198806
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C42-H69-N-O15.C3-H7-O4
MOLECULAR WEIGHT        : 935.22
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (-)-cis-1,2-Epoxypropylphosphonate de josamycine
   * Josamycin fosfomycin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 418 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BEXXAL Belgian Patent Document.  (U.S. Patent and Trademark Office, Foreign
   Patents, Washington, DC 20231)  Volume(issue)/page/year: #900760
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 386 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BEXXAL Belgian Patent Document.  (U.S. Patent and Trademark Office, Foreign
   Patents, Washington, DC 20231)  Volume(issue)/page/year: #900760
 
                            *** END OF RECORD ***