*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OK6370800
CHEMICAL NAME           : Luteinizing hormone releasing factor (pig),
                          6-(1-(phenylmethyl)-D-histidine)-9-(N-ethyl-L-
                          prolinamide)-10-deglycinamide-
CAS REGISTRY NUMBER     : 76712-82-8
BEILSTEIN REFERENCE NO. : 4290557
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C66-H86-N18-O12
MOLECULAR WEIGHT        : 1323.70
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Histrelin
   * ((ImBl)-D-His(sub 6),Pro(sub 9)-NEt)LHRH
   * ORF 17070
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 46 ug/kg
SEX/DURATION            : male 2 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal Fulfillment Dept.,
   2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1980-
   Volume(issue)/page/year: 7,140,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4667 ug/kg
SEX/DURATION            : male 8 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal Fulfillment Dept.,
   2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1980-
   Volume(issue)/page/year: 7,140,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2333 ug/kg
SEX/DURATION            : male 4 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   JOAND3 Journal of Andrology.  (Lippincott/Harper, Journal Fulfillment Dept.,
   2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1980-
   Volume(issue)/page/year: 7,140,1986
 
                            *** END OF RECORD ***