*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OK6377200
CHEMICAL NAME           : Luteinizing hormone-releasing hormone, (AC-delta(sup
                          3)-pro(sup 1)-p-Cl-D-phe(sup 2)- D-trp(sup 3,6))-
CAS REGISTRY NUMBER     : 80152-22-3
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * (AC-delta(sup 3)-Pro(sup 1)-4-Cl-D-phe(sup 2)-D-trp(sup 3,6))-Gnrh
   * (AC-delta(sup 3)-Pro(sup 1)-4-Cl-D-phe(sup 2)-D-trp(sup  
   3,6))-gonadotropin releasing hormone
   * (AC-delta(sup 3)-Pro(sup 1)-4-Cl-D-phe(sup 2)-D-trp(sup 3,6))-LHRH
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7500 ug/kg
SEX/DURATION            : female 8-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   110,347,1982
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 130 mg/kg
SEX/DURATION            : female 26 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 26,1545,1983
 
                            *** END OF RECORD ***