*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OK6420000
CHEMICAL NAME : Luteinizing hormone-releasing factor (pig),
6-D-alanine-9-N-ethyl-L-prolinamide)-10-
deglicinamide-
CAS REGISTRY NUMBER : 52435-06-0
OTHER CAS REGISTRY NOS. : 56136-33-5
BEILSTEIN REFERENCE NO. : 0906592
LAST UPDATED : 199706
DATA ITEMS CITED : 20
MOLECULAR FORMULA : C56-H78-N16-O12
MOLECULAR WEIGHT : 1167.50
COMPOUND DESCRIPTOR : Reproductive Effector
Human
Hormone
SYNONYMS/TRADE NAMES :
* (D-Ala(sup 6)-des-gly-NH2(sup 10))LHRH ethylamide
* (D-Ala(sup 6)-des-gly-NH2(sup 10))-luteinizing hormone-releasing hormone
ethylamide
* 6-D-Alanine-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing
hormone-releasing hormone
* AY-25,205
* TAP 127
* WY 18481
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia
REFERENCE :
AEFTAA Acta Europaea Fertilitatis. (COFESE Eds., Piazzale Ungheria 73,
90141 Palermo, Italy) V.1- 1969- Volume(issue)/page/year: 11,113,1980
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Human - woman
DOSE : 12 ug/kg
SEX/DURATION : female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
Volume(issue)/page/year: 11(4),29,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Human - woman
DOSE : 30 ug/kg
SEX/DURATION : female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
Volume(issue)/page/year: 11(4),29,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Human - woman
DOSE : 20 ug/kg
SEX/DURATION : female 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - oogenesis
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Maternal Effects - other effects
REFERENCE :
SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980-
Volume(issue)/page/year: 11(4),29,1991
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 3500 ug/kg
SEX/DURATION : female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 30 mg/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 300 ug/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 2500 ng/kg
SEX/DURATION : male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
103,641,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 8400 ug/kg
SEX/DURATION : male 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept.,
2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980-
Volume(issue)/page/year: 2,152,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 360 ng/kg
SEX/DURATION : male 9 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W.
Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year:
22,1094,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 35 ug/kg
SEX/DURATION : female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 50 ng/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females
per # females mated; # copulations per # estrus cycles)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot,
POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 44,87,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 100 ng/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S,
Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1078,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 500 ug/kg
SEX/DURATION : female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 32 ug/kg
SEX/DURATION : male 8 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - other effects on male
REFERENCE :
JSTBBK Journal of Steroid Biochemistry. (Pergamon Press Ltd., Headington
Hill Hall, Oxford OX3 0BW, UK) V.1- 1969- Volume(issue)/page/year:
13,191,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 2100 ug/kg
SEX/DURATION : female 84 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
104,1369,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 2 ug/kg
SEX/DURATION : male 4 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
104,1369,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 8 ug/kg
SEX/DURATION : male 16 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year:
104,1369,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 7 ug/kg
SEX/DURATION : female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE : 6 ug/kg
SEX/DURATION : female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
IJGOAL International Journal of Gynaecology & Obstetrics. (Elsevier
Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.7- 1969-
Volume(issue)/page/year: 16,359,1979
*** END OF RECORD ***