*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : OK6508000 CHEMICAL NAME : Luteinizing hormone-releasing hormone, (D-his(sub 6)(IM-bzl)-pro(sup 9)-NEt)- LAST UPDATED : 198910 DATA ITEMS CITED : 3 COMPOUND DESCRIPTOR : Reproductive Effector Hormone SYNONYMS/TRADE NAMES : * Gonadotropin releasing hormone, (D-his(sub 6)(IM-bzl)-pro(sup 9)-NEt)- * (D-His(sup 6)(Im-bzl)-pro(sup 9)-NEt)-GNRH * (D-His(sup 6)(IM-bzl)-pro(sup 9)-NEt)-gonadotropin releasing hormone * (D-His(sup 6)(IM-bzl)-pro(sup 9)-NEt)-LHRH * (D-His(sup 6)(IM-bzl)-pro(sup 9)-NEt)-luteinizing hormone-releasing hormone *** HEALTH HAZARD DATA *** ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 112 ug/kg SEX/DURATION : male 28 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 31,91,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 112 ug/kg SEX/DURATION : female 28 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 31,91,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE : 92500 ng/kg SEX/DURATION : female 37 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1545,1983 *** END OF RECORD ***