*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OK6508000
CHEMICAL NAME           : Luteinizing hormone-releasing hormone, (D-his(sub
                          6)(IM-bzl)-pro(sup 9)-NEt)-
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * Gonadotropin releasing hormone, (D-his(sub 6)(IM-bzl)-pro(sup 9)-NEt)-
   * (D-His(sup 6)(Im-bzl)-pro(sup 9)-NEt)-GNRH
   * (D-His(sup 6)(IM-bzl)-pro(sup 9)-NEt)-gonadotropin releasing hormone
   * (D-His(sup 6)(IM-bzl)-pro(sup 9)-NEt)-LHRH
   * (D-His(sup 6)(IM-bzl)-pro(sup 9)-NEt)-luteinizing hormone-releasing  
   hormone
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 112 ug/kg
SEX/DURATION            : male 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 31,91,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 112 ug/kg
SEX/DURATION            : female 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 31,91,1985
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 92500 ng/kg
SEX/DURATION            : female 37 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 26,1545,1983
 
                            *** END OF RECORD ***