*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OK6671000
CHEMICAL NAME           : Luteinizing hormone-releasing hormone, (D-phe(sup
                          2)-D-(PH)gly(sup 6))-
CAS REGISTRY NUMBER     : 56558-32-8
LAST UPDATED            : 199312
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Hormone
SYNONYMS/TRADE NAMES :
   * (Des-gly10)-D-ala6-pro9-ethylamide-LHRH
   * (D-Phe(sup 2)-D-(PH)gly(sup 6))-LHRH
   * (D-Phe(sup 2)-D-(PH)gly(sup 6))-luteinizing hormone-releasing hormone
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,1247,1975
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - horse, donkey
DOSE                    : 11 ug/kg
SEX/DURATION            : female 12 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   THGNBO Theriogenology.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1974-  Volume(issue)/page/year: 38,33,1992
 
                            *** END OF RECORD ***