*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OK6684000
CHEMICAL NAME           : Luteinizing hormone-releasing hormone, (D-phe(sup
                          2)-D-trp(sup 3)-D-phe(sup 6))-
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Human
                          Hormone
SYNONYMS/TRADE NAMES :
   * Luteinizing hormone-releasing hormone, (D-phe-2,D-trp-3,D-phe-6)-
   * (D-Phe-2,D-trp-3,D-phe-6)-LHRH
   * (D-Phe(sup 2)-D-trp(sup 3)-D-phe(sup 6))-LHRH
   * (D-Phe-2,D-trp-3,D-phe-6)-luteinizing hormone-releasing hormone
   * (D-Phe(sup 2)-D-trp(sup 3)-D-phe(sup 6))-luteinizing hormone-releasing  
   hormone
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - man
DOSE                    : 1286 ug/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,997,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - woman
DOSE                    : 1800 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Maternal Effects - other effects
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   INJFA3 International Journal of Fertility.  (Allen Press, 1041 New
   Hampshire,  St., Lawrence, KS 66044)  V.1-    1955- Volume(issue)/page/year:
   25,190,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 21,276,1978
 
                            *** END OF RECORD ***