*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OL2900000
CHEMICAL NAME           : Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-
CAS REGISTRY NUMBER     : 476-28-8
LAST UPDATED            : 199709
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C16-H17-N-O4
MOLECULAR WEIGHT        : 287.34
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Amarylline
   * Galanthan-1,2-diol, 3,12-didehydro-9,10-(methylenebis(oxy))-,  
   (1-alpha,2-beta)-
   * Galanthidine
   * Lycorine
   * (-)-Lycorine
   * Narcissine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10700 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   56(1),23S,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   56(1),23S,1960
 
                            *** END OF RECORD ***