*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OI6180000
CHEMICAL NAME           : Ligroine
CAS REGISTRY NUMBER     : 8032-32-4
OTHER CAS REGISTRY NOS. : 8031-06-9
LAST UPDATED            : 199712
DATA ITEMS CITED        : 18
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Benzine (light petroleum distillate)
   * Benzoline
   * Canadol
   * Ligroin
   * Painters naphtha
   * Petroleum ether
   * Refined solvent naphtha
   * Skellysolve F
   * Skellysolve G
   * Varnish marker's naphtha
   * VM and P Naphtha
   * VM & P Naphtha
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Human
DOSE/DURATION           : 880 ppm/15M
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   32,263,1975
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3400 ppm/4H
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   32,263,1975
 
TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 153 gm/m3/31M
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   BIZEA2 Biochemische Zeitschrift.  (Berlin, Ger.)  V.1-346, 1906-67.  For
   publisher information, see EJBCAI.  Volume(issue)/page/year: 115,235,1921
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 7,765,1973
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/m3/4H
SEX/DURATION            : female 1-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 56(9),35,1991

                              *** REVIEWS ***
 
   ACGIH TLV-Animal carcinogen
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   ACGIH TLV-TWA 1370 mg/m3 (300 ppm)
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
   FEREAC Federal Register.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402) V.1-    1936-  Volume(issue)/page/year:
   54,7740,1989

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO VM & P NAPHTHA-air:10H TWA 350 mg/m3;CL 1800 mg/m3/15M
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M0630
       No. of Facilities: 1437 (estimated)
       No. of Industries: 21
       No. of Occupations: 22
       No. of Employees: 10998 (estimated)
   
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M2829
       No. of Facilities: 182022 (estimated)
       No. of Industries: 459
       No. of Occupations: 231
       No. of Employees: 2414497 (estimated)
   
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - T0180
       No. of Facilities: 1133 (estimated)
       No. of Industries: 16
       No. of Occupations: 12
       No. of Employees: 3524 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M0630
       No. of Facilities: 5 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 1674 (estimated)
       No. of Female Employees: 109 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - T0180
       No. of Facilities: 93614 (estimated)
       No. of Industries: 337
       No. of Occupations: 196
       No. of Employees: 1319179 (estimated)
       No. of Female Employees: 164513 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NIOSH Analytical Method, 1994: Naphthas, 1550

 
                            *** END OF RECORD ***