*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : ON9104700
CHEMICAL NAME           : Malonamic acid,
                          N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3
                          .2.0)hept-6-yl)-2- phenyl-
CAS REGISTRY NUMBER     : 4697-36-3
LAST UPDATED            : 199712
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C17-H18-N2-O6-S
MOLECULAR WEIGHT        : 378.43
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Carbenicillin
   * Carboxybenzylpenicillin
   * (alpha-Carboxybenzyl)penicillin
   * Carboxybenzylpenicillin acid
   * Pyocianil
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2363 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 29,361,1984
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 280 mg/L
REFERENCE :
   HUTODJ Human Toxicology.  (Macmillan Press Ltd., Houndmills, Basingstoke,
   Hants., RG 21 2XS, UK) V.1-    1981-  Volume(issue)/page/year: 3,173,1984

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X3591
       No. of Facilities: 178 (estimated)
       No. of Industries: 1
       No. of Occupations: 5
       No. of Employees: 10079 (estimated)
       No. of Female Employees: 8399 (estimated)

 
                            *** END OF RECORD ***