*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OO3675000
CHEMICAL NAME : Malononitrile, o-chlorobenzylidene-
CAS REGISTRY NUMBER : 2698-41-1
BEILSTEIN REFERENCE NO. : 1866635
REFERENCE : 2-09-00-00641 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 60
MOLECULAR FORMULA : C10-H5-Cl-N2
MOLECULAR WEIGHT : 188.62
WISWESSER LINE NOTATION : NCYCN&U1R BG
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* (o-Chlorobenzal)malononitrile
* 2-Chlorobenzalmalononitrile
* o-Chlorobenzylidene malonitrile
* 2-Chlorobenzylidene malononitrile
* o-Chlorobenzylidene malononitrile
* 2-Chlorobmn
* CS
* beta,beta-Dicyano-o-chlorostyrene
* NCI-C55118
* Propanedinitrile, ((2-chlorophenyl)methylene)
* USAF KF-11
* TL 238
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Human
DOSE/DURATION : 10 mg/1H
REACTION SEVERITY : Mild
REFERENCE :
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB
88, Oxford, UK) V.63- 1951- Volume(issue)/page/year: 90,657,1974
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Human - man
DOSE/DURATION : 5 mg/m3/20S
REACTION SEVERITY : Severe
REFERENCE :
MMEDA9 Military Medicine. (Assoc. of Military Surgeons of the United
States, Box 104, Kensington, MD 20795) V.116- 1955-
Volume(issue)/page/year: 134,219,1969
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Human - man
DOSE/DURATION : 624 ng
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
35,412,1974
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 12%/6H
REACTION SEVERITY : Mild
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 12%/6H
REACTION SEVERITY : Mild
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 5 mg
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
4,656,1962
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 mg
REACTION SEVERITY : Mild
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
17,295,1970
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1150 ng
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
35,412,1974
TYPE OF TEST : Open irritation test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 12%/6H
REACTION SEVERITY : Mild
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 429 ng
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
35,412,1974
** ACUTE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 1500 ug/m3/90M
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
6,366,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 178 mg/kg
TOXIC EFFECTS :
Gastrointestinal - gastritis
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
24,449,1972
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1806 mg/m3/45M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - hemorrhage
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 48 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
24,45,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 28 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - respiratory stimulation
Kidney, Ureter, Bladder - other changes
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 282 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD837-111
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2753 mg/m3/20M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - hemorrhage
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 32320 ug/kg
TOXIC EFFECTS :
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,73,1981
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
4,656,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 47700 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
25,111,1973
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 2600 mg/m3/23M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 30(1),86,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 143 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - other changes
Skin and Appendages - hair
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1802 mg/m3/10M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - hemorrhage
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 32065 ug/kg
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,64,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 8 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
4,656,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 212 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - other changes
Skin and Appendages - hair
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2326 mg/m3/10M
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - acute pulmonary edema
Blood - hemorrhage
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
40,75,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 73 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - other changes
Skin and Appendages - hair
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
40,75,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/m3/6H/14D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-377,1990
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1500 ug/m3/6H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-377,1990
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10 mg/m3/6H/14D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-377,1990
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3 mg/m3/6H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-377,1990
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 160 mg/kg/10D-I
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in thymus weight
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 26,571,1981
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 6 mg/m3/5M
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
37QLAZ "Current Approaches in Toxicology," Ballantyne, B., ed., Bristol, UK,
John Wright & Sons, Ltd., 1977 Volume(issue)/page/year: -,79,1977
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
49,15,1981
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 2500 ug/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
11,91,1988
TYPE OF TEST : Micronucleus test
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 19 umol/L
REFERENCE :
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year:
63,314,1989
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 6 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-377,1990
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 9400 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 282,231,1992
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 10 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-377,1990
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 18800 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 282,231,1992
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-CL 0.39 mg/m3 (0.05 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.05 ppm (0.4 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,50,1971
OSHA PEL (Gen Indu):8H TWA 0.05 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.05 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.05 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.05 ppm (0.4 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.05 ppm (0.4 mg/m3);Skin JAN 1993
OEL-BELGIUM:STEL 0.05 ppm (0.4 mg/m3);Skin JAN 1993
OEL-DENMARK:STEL 0.05 ppm (0.4 mg/m3);Skin JAN 1993
OEL-FRANCE:STEL 0.05 ppm (0.4 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 0.05 ppm (0.4 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:.TWA 05 ppm (0.4 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.05 ppm (0.4 mg/m3);Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO o-CHLOROBENZYLIDENEMALONONITRILE-air:CL 0.05 ppm (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis Studies (inhalation);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-377,90
*** END OF RECORD ***