*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OO7340000
CHEMICAL NAME           : Mandelic acid, alpha-cyclopentyl-,
                          1-methyl-3-pyrrolidinyl ester, hydrochloride
CAS REGISTRY NUMBER     : 13118-10-0
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C18-H25-N-O3.Cl-H
MOLECULAR WEIGHT        : 339.90
WISWESSER LINE NOTATION : T5NTJ A1 COVXQR&- AL5TJ &GH
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * AHR 376
   * alpha-Cyclopentylmandelic acid 1-methyl-3-pyrrolidinyl ester  
   hydrochloride
   * 1-Methyl-3-pyrrolidyl alpha-phenylcyclopentaneglycolate hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 14 ug/kg/D
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - toxic psychosis
REFERENCE :
   CPAJAK Canadian Psychiatric Association Journal.  (Ottawa, Ont., Canada)
   V.1-23, 1956-78.  For publisher information, see CJPSDF.
   Volume(issue)/page/year: 11,S141,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JMPCAS Journal of Medicinal and Pharmaceutical Chemistry.  (Washington, DC)
   V.1-5, 1959-62.  For publisher information, see JMCMAR.
   Volume(issue)/page/year: 2,523,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JMPCAS Journal of Medicinal and Pharmaceutical Chemistry.  (Washington, DC)
   V.1-5, 1959-62.  For publisher information, see JMCMAR.
   Volume(issue)/page/year: 2,523,1960
 
                            *** END OF RECORD ***