*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OP2275000
CHEMICAL NAME : Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-,
dihydrochloride, D-
CAS REGISTRY NUMBER : 551-74-6
LAST UPDATED : 199707
DATA ITEMS CITED : 21
MOLECULAR FORMULA : C10-H22-Cl2-N2-O4.2Cl-H
MOLECULAR WEIGHT : 378.16
WISWESSER LINE NOTATION : G2M1YQYQYQYQ1M2G &GH 2
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 1,6-Bis-(chloroethylamino)-1,6-dideoxy-D-mannite dihydrochloride
* 1,6-Bis(beta-chloroethylamino)-1,6-dideoxy-D-mannitol dihydrochloride
* Degranol
* Degranol chinoin
* 1,6-Dideoxy-1,6-di(2-chloroethylamino)-D-mannitol dihydrochloride
* Dimesylmannitol
* D-Mannitol, 1,6-bis(2-(chloroethyl)amino)-1,6-dideoxy-, dihydrochloride
* Mannogranol
* Mannomustine dihydrochloride
* NSC-9698
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great
Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
Volume(issue)/page/year: 18,760,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1965-
Volume(issue)/page/year: 52,76,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 11,529,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RFECAC Revue Francaise d'Etudes Cliniques et Biologiques. (Paris, France)
V.1-14, 1956-69. For publisher information, see BIMDB3.
Volume(issue)/page/year: 7,296,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
17TVAO "Radiation-Induced Cancer, Proceedings of a Symposium, Athens, 1969,"
Lanham, MD, Bernan-UNIPUB, 1969 Volume(issue)/page/year: -,97,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
1957- Volume(issue)/page/year: 11,529,1964
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 7600 ug/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
Blood - leukopenia
Blood - thrombocytopenia
REFERENCE :
CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5,
1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year:
2,201,1965
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Blood - leukopenia
Blood - thrombocytopenia
Blood - other changes
REFERENCE :
CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5,
1964-75. For publisher information, see CTRRDO. Volume(issue)/page/year:
2,201,1965
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 260 mg/kg/4D-I
TOXIC EFFECTS :
Liver - other changes
Blood - changes in spleen
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 120,334,1959
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 23 mg/kg/4W
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
36,915,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7265 ug/kg/4W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
36,915,1966
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK.
(Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
Volume(issue)/page/year: 8(6),44,1974
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 20 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 21,190,1973
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Leukocyte
DOSE/DURATION : 6 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 14,345,1972
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 10 umol/L
REFERENCE :
IPPABX Iugoslavica Physiologica et Pharmacologica Acta. (Jugoslovenska
Knjiga, POB 36, YU-11001 Belgrade, Yugoslavia) V.1- 1965-
Volume(issue)/page/year: 17,131,1981
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 3 umol/L
REFERENCE :
IPPABX Iugoslavica Physiologica et Pharmacologica Acta. (Jugoslovenska
Knjiga, POB 36, YU-11001 Belgrade, Yugoslavia) V.1- 1965-
Volume(issue)/page/year: 17,131,1981
TYPE OF TEST : DNA damage
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 200 mg/kg
REFERENCE :
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd.,
London NW1 7DX, UK) V.1- 1955- Volume(issue)/page/year: 25,380,1979
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Bacteria - Escherichia coli
DOSE/DURATION : 1 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 21,190,1973
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,157,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 9,157,1975
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** END OF RECORD ***