*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : OP2282000 CHEMICAL NAME : D-Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-, mixt. with heparin CAS REGISTRY NUMBER : 39366-34-2 LAST UPDATED : 198803 DATA ITEMS CITED : 3 SYNONYMS/TRADE NAMES : * Heparin-degranol * Zitofenton *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 115 mg/kg TOXIC EFFECTS : Gastrointestinal - other changes Blood - hemorrhage Blood - changes in bone marrow (not otherwise specified) REFERENCE : NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 16,137,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 185 mg/kg TOXIC EFFECTS : Gastrointestinal - other changes Blood - hemorrhage Blood - changes in bone marrow (not otherwise specified) REFERENCE : NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 16,137,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 287 mg/kg TOXIC EFFECTS : Gastrointestinal - other changes Blood - hemorrhage Blood - changes in bone marrow (not otherwise specified) REFERENCE : NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 16,137,1969 *** END OF RECORD ***