*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OP2282000
CHEMICAL NAME           : D-Mannitol,
                          1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-, mixt.
                          with heparin
CAS REGISTRY NUMBER     : 39366-34-2
LAST UPDATED            : 198803
DATA ITEMS CITED        : 3
SYNONYMS/TRADE NAMES :
   * Heparin-degranol
   * Zitofenton
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 115 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - hemorrhage
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 16,137,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 185 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - hemorrhage
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 16,137,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 287 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - hemorrhage
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   NEOLA4 Neoplasma.  (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4-
      1957-  Volume(issue)/page/year: 16,137,1969
 
                            *** END OF RECORD ***