*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OP2450000
CHEMICAL NAME           : Mannitol, 1,2:5,6-dianhydro-, D-
CAS REGISTRY NUMBER     : 19895-66-0
LAST UPDATED            : 199109
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C6-H10-O4
MOLECULAR WEIGHT        : 146.16
WISWESSER LINE NOTATION : VH1YQYQ1VH
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Dianhydromannitol
   * 1:2:5:6-Dianhydro-D-mannitol
   * NSC-133129
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - thrombocytopenia
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 4,617,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Blood - granulocytopenia
   Blood - other changes
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   EJCODS European Journal of Cancer and Clinical Oncology.  (Pergamon Press,
   c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591)  V.17(7)-
   25, 1981-89.  For publisher information, see EJCAEL Volume(issue)/page/year:
   18,573,1982
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bird - chicken Leukocyte
DOSE/DURATION           : 30 mmol/L
REFERENCE :
   TELEAY Tetrahedron Letters.  (Pergamon Press Ltd., Headington Hill Hall,
   Oxford OX3 OBW, UK)  1959-  Volume(issue)/page/year: (29),2477,1975
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rabbit Bone marrow
DOSE/DURATION           : 274 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   25,1705,1976
 
                            *** END OF RECORD ***