*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : OP2450000 CHEMICAL NAME : Mannitol, 1,2:5,6-dianhydro-, D- CAS REGISTRY NUMBER : 19895-66-0 LAST UPDATED : 199109 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C6-H10-O4 MOLECULAR WEIGHT : 146.16 WISWESSER LINE NOTATION : VH1YQYQ1VH COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * Dianhydromannitol * 1:2:5:6-Dianhydro-D-mannitol * NSC-133129 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 14 mg/kg TOXIC EFFECTS : Blood - normocytic anemia Blood - thrombocytopenia REFERENCE : EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981. For publisher information, see EJCODS. Volume(issue)/page/year: 4,617,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Blood - granulocytopenia Blood - other changes Tumorigenic - active as anti-cancer agent REFERENCE : EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 18,573,1982 ** MUTATION DATA ** TYPE OF TEST : DNA damage TEST SYSTEM : Bird - chicken Leukocyte DOSE/DURATION : 30 mmol/L REFERENCE : TELEAY Tetrahedron Letters. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) 1959- Volume(issue)/page/year: (29),2477,1975 TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - rabbit Bone marrow DOSE/DURATION : 274 umol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,1705,1976 *** END OF RECORD ***