*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OS9275000
CHEMICAL NAME           : p-Menthane, 1,8-epoxy-
CAS REGISTRY NUMBER     : 470-82-6
LAST UPDATED            : 199710
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C10-H18-O
MOLECULAR WEIGHT        : 154.28
WISWESSER LINE NOTATION : T66 A B AOTJ B1 B1 F1
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Cajeputol
   * 1,8-Cineol
   * Cineole
   * 1,8-Cineole
   * 1,8-Epoxy-p-menthane
   * Eucalyptol
   * Eucalyptole
   * Eukalyptol
   * NCI-C56575
   * 2-Oxabicyclo(2.2.2)octane, 1,3,3-trimethyl-
   * 1,8-Oxido-p-menthane
   * Terpan
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2480 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - coma
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 2,327,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1070 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   SIZSAR Sapporo Igaku Zasshi.  Sapporo Medical Journal.  (Sapporo Igaku
   Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan)  V.3-
   1952-  Volume(issue)/page/year: 3,73,1952
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JSICAZ Journal of Scientific and Industrial Research, Section C: Biological
   Sciences.  (New Delhi, India)  V.14-21, 1955-62.  For publisher information,
   see IJEBA6.  Volume(issue)/page/year: 21,342,1962
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   TFAKA4 Trudy Instituta Fiziologii, Akademiya Nauk Kazakhshoi SSR.
   Transactions of the Institute of Physiology, Academy of Sciences of the
   Kazakh. SSR.  (Izdatel'stvo Nauka Kazakhskoi SSR, Alma- Ata, USSR)  V.1-
   1955-  Volume(issue)/page/year: 1,134,1955
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TFAKA4 Trudy Instituta Fiziologii, Akademiya Nauk Kazakhshoi SSR.
   Transactions of the Institute of Physiology, Academy of Sciences of the
   Kazakh. SSR.  (Izdatel'stvo Nauka Kazakhskoi SSR, Alma- Ata, USSR)  V.1-
   1955-  Volume(issue)/page/year: 1,134,1955
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 gm/kg
SEX/DURATION            : female 19-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   22,543,1973
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   DPIRDU Dangerous Properties of Industrial Materials Report.  (Van Nostrand
   Reinhold, 115 Fifth Ave., New York, NY 10003)  V.1-    1981-
   Volume(issue)/page/year: 2(4),10,1982

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 19540
       No. of Facilities: 1103 (estimated)
       No. of Industries: 11
       No. of Occupations: 23
       No. of Employees: 5213 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 19540
       No. of Facilities: 4397 (estimated)
       No. of Industries: 48
       No. of Occupations: 57
       No. of Employees: 83399 (estimated)
       No. of Female Employees: 20158 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***