*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : OS9541500
CHEMICAL NAME           : p-Menthan-3-one, dl-
CAS REGISTRY NUMBER     : 1074-95-9
LAST UPDATED            : 199701
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H18-O
MOLECULAR WEIGHT        : 154.28
WISWESSER LINE NOTATION : L6VTJ BY1&1 E1 -R
COMPOUND DESCRIPTOR     : Natural Product
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * Cyclohexan-1-one, 2-isopropyl-5-methyl-, racemic
   * p-Menthan-3-one racemic
   * Menthone racemic
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/24H
REACTION SEVERITY       : Mild
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 14,475,1976
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 14,475,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 14,475,1976
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18788 mg/kg/4W-I
TOXIC EFFECTS :
   Brain and Coverings - changes in brain weight
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 32,147,1986
 
                            *** END OF RECORD ***