*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : OV4550000
CHEMICAL NAME : Mercury
CAS REGISTRY NUMBER : 7439-97-6
OTHER CAS REGISTRY NOS. : 8030-64-6
51887-47-9
92355-34-5
92786-62-4
123720-03-6
LAST UPDATED : 199806
DATA ITEMS CITED : 75
MOLECULAR FORMULA : Hg
MOLECULAR WEIGHT : 200.59
WISWESSER LINE NOTATION : HG
COMPOUND DESCRIPTOR : Agricultural Chemical
Tumorigen
Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Colloidal mercury
* Hydrargyrum
* KWIK
* Liquid silver
* Mercure
* Mercurio
* Mercury
* Metallic mercury
* NCI-C60399
* Quecksilber
* Quick silver
* RCRA waste number U151
* RTEC
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 254 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 2,243,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 43 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Liver - jaundice, other or unclassified
Liver - other changes
REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270
Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year:
31,487,1993
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - man
DOSE/DURATION : 44300 ug/m3/8H
TOXIC EFFECTS :
Behavioral - muscle weakness
Liver - other changes
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational
Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
Volume(issue)/page/year: 20,532,1978
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 150 ug/m3/46D
TOXIC EFFECTS :
Behavioral - wakefulness
Behavioral - anorexia (human)
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
33,186,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Human - man
DOSE/DURATION : 129 mg/kg/5H-C
TOXIC EFFECTS :
Sense Organs and Special Senses (Ear) - tinnitus
Behavioral - headache
Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
DERAAC Dermatologica. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY
10003) V.79- 1939- Volume(issue)/page/year: 172,48,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - man
DOSE/DURATION : 571 uL/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - sweating
REFERENCE :
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446,
Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 90,1033,1997
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 29 mg/m3/30H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 7,19,1953
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 mg/m3/24H/5W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - proteinuria
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 79,119,1993
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8 ug/m3/6.5H/41W-I
TOXIC EFFECTS :
Behavioral - alteration of classical conditioning
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 27(1),7,1962
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 17 mg/m3/2H/30D-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Behavioral - alteration of classical conditioning
Behavioral - alteration of operant conditioning
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
12,15,1968
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg/14D-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75,
1903-71. For publisher information, see JCROD7. Volume(issue)/page/year:
61,511,1957
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 890 ng/m3/24H
SEX/DURATION : male 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 45(3),72,1980
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 7440 ng/m3/24H
SEX/DURATION : male 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 45(3),72,1980
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 1 mg/m3/24H
SEX/DURATION : female 1-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 35,59A,1987
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Human - man
DOSE/DURATION : 150 ug/m3
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
34,461,1979
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 0.025 mg(Hg)/m3, vapor (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,239,1993
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,239,1993
IARC Cancer Review:Group 3
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 58,239,1993
TOXICOLOGY REVIEW
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co.,
11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
Volume(issue)/page/year: 126,390,1976
TOXICOLOGY REVIEW
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 2,491,1977
TOXICOLOGY REVIEW
TRBMAV Texas Reports on Biology and Medicine. (Galveston, TX) V.1-41(2),
1943-81/82. Discontinued. Volume(issue)/page/year: 33,85,1975
TOXICOLOGY REVIEW
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1
Lambeth High St., London, SE1 7JN, UK) V.131- 1933-
Volume(issue)/page/year: 213,159,1974
TOXICOLOGY REVIEW
JDSCAE Journal of Dairy Science. (American Dairy Science Assoc., 309 W.
Clark St., Champaign, IL 61820) V.1- 1917- Volume(issue)/page/year:
58,1767,1975
TOXICOLOGY REVIEW
CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal
Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962-
Volume(issue)/page/year: 13,783,1974
TOXICOLOGY REVIEW
QURBAW Quarterly Reviews of Biophysics. (Cambridge Univ. Press, The
Edinburgh Bldg., Shaftesbury Rd., Cambridge CB2 2RU, UK) V.1- 1968-
Volume(issue)/page/year: 7,75,1974
TOXICOLOGY REVIEW
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year:
48,463,1974
TOXICOLOGY REVIEW
JAVMA4 Journal of the American Veterinary Medical Association. (American
Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48-
1915- Volume(issue)/page/year: 164,277,1974
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate
Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year:
2,365,1973
TOXICOLOGY REVIEW
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year:
40,239,1973
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 5,151,1972
TOXICOLOGY REVIEW
BIOGAL Biologico. (Instituto Biologica, Av. Cons. Rodriques Alves, 1252,
CEP 04014, Sao Paulo, Brazil) V.1- 1935- Volume(issue)/page/year:
41(7),208,1975
TOXICOLOGY REVIEW
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 5,51,1972
TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
42,103,1972
TOXICOLOGY REVIEW
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher
information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942
TOXICOLOGY REVIEW
NISIA9 Nippon Shika Ishikai Zasshi. Journal of the Japan Dental
Association. (Nippon Shika Ishikai, 1-20 Kudan-kita, 4-chome, Chiyoda-ku,
Tokyo, 102 Japan) V.1- 1948- Volume(issue)/page/year: 27,942,1974
TOXICOLOGY REVIEW
MIBUBI Mikrobiyoloji Bulteni. Bulletin of Microbiology. (c/o Dr. A. Tevfik
Cenqiz, Ankara Universitesi Tip Fakultesi Mikrobiyoloji Ana Bilim Dah,
Ankara, Turkey) V.1- 1967- Volume(issue)/page/year: 9,321,1975
TOXICOLOGY REVIEW
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- 1972- Volume(issue)/page/year:
2,341,1974
TOXICOLOGY REVIEW
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 13,36,1977
TOXICOLOGY REVIEW
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer
Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year:
5,63,1970
TOXICOLOGY REVIEW
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67.
For publisher information, see:JJOMDZ Volume(issue)/page/year: 2,337,1960
TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year:
12,102,1969
TOXICOLOGY REVIEW
PDTNBH Paediatrician. (S. Karger AG, Postfach CH-4009 Basel, Switzerland)
V.1- 1972- Volume(issue)/page/year: 6,204,1977
TOXICOLOGY REVIEW
49DXAV "Health Evaluation of Heavy Metals in Infant Formula and Junior Food,
Proceedings of the Symposium, 1981," Schmidt, E.H.F., and A.G. Hildebrandt,
eds., Berlin, Springer-Verlag, 1983 Volume(issue)/page/year: -,57,1983
*** U.S. STANDARDS AND REGULATIONS ***
OSHA PEL (Gen Indu):CL 0.1 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.1 mg(Hg)/m3 , vapor (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):CL 0.1 mg/m3,vapor (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.05 mg/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.1 mg/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.1 mg/m3;Skin JAN 1993
OEL-FINLAND:TWA 0.05 mg/m3 JAN 1993
OEL-FRANCE:TWA 0.05 mg/m3;Skin (vapor) JAN 1993
OEL-FRANCE:TWA 0.1 mg/m3;Skin JAN 1993
OEL-HUNGARY:TWA 0.02 mg/m3;STEL 0.04 mg/m3 JAN 1993
OEL-POLAND:TWA 0.05 mg/m3 JAN 1993
OEL-SWEDEN:TWA 0.05 mg/m3 (vapor) JAN 1993
OEL-SWITZERLAND:TWA 0.005 ppm (0.05 mg/m3);Skin (vapor) JAN 1993
OEL-SWITZERLAND:TWA 0.01 mg/m3;Skin JAN 1993
OEL-TURKEY:TWA 0.1 mg/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO MERCURY, vapor (as Hg)-air:10H TWA 0.05 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 44870
No. of Facilities: 2072 (estimated)
No. of Industries: 32
No. of Occupations: 36
No. of Employees: 15002 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 44870
No. of Facilities: 2937 (estimated)
No. of Industries: 42
No. of Occupations: 67
No. of Employees: 71932 (estimated)
No. of Female Employees: 23826 (estimated)
*** STATUS IN U.S. ***
ATSDR TOXICOLOGY PROFILE
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB/181256/AS
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Mercury, 6009
NIOSH Analytical Method, 1996: Mercury, 6009
OSHA ANALYTICAL METHOD #ID-185S
*** END OF RECORD ***