*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : PA3500000
CHEMICAL NAME           : Methane, 2,2'-bis(6-t-butyl-p-cresyl)-
CAS REGISTRY NUMBER     : 119-47-1
BEILSTEIN REFERENCE NO. : 2062676
REFERENCE               : 4-06-00-06801 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C23-H32-O2
MOLECULAR WEIGHT        : 340.55
WISWESSER LINE NOTATION : 1X1&1&R BQ C3R BQ CX1&1&1
COMPOUND DESCRIPTOR     : Primary Irritant
SYNONYMS/TRADE NAMES :
   * Advastab 405
   * Antage W 400
   * Antioxidant 1
   * Anti Ox
   * Antioxidant 2246
   * Antioxidant BKF
   * Antioxidant NG-2246
   * AO1
   * AO 2246
   * AO 1 (Antioxidant)
   * Bisaklofen BP
   * 2,2'-Bis-6-terc.butyl-p-kresylmethan
   * BKF
   * CAO 5
   * CAO 14
   * Calco 2246
   * Catolin 14
   * Chemanox 21
   * p-Cresol, 2,2'-methylenebis(6-tert-butyl-
   * Lederle 2246
   * 2,2'-Methylene-bis(6-tert-butyl-4-methylphenol)
   * 2,2''-Methylenebis(4-methyl-6-tert-butylphenol)
   * NG 2246
   * Nocrac NS 6
   * Oxy Chek 114
   * Plastanox 2246
   * Synox 5LT
   * Vulkanox BKF
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/24H
REACTION SEVERITY       : Moderate
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,240,1986
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 38(8),28,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 11 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 19,77,1994
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1623 mg/kg/1W-C
TOXIC EFFECTS :
   Liver - other changes
   Blood - changes in other cell count (unspecified)
   Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 8,77,1981
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25200 mg/kg/12W-C
TOXIC EFFECTS :
   Blood - pigmented or nucleated red blood cells
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 19,77,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 23096 mg/kg/78W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - changes in testicular weight
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 19,77,1994

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 82995
       No. of Facilities: 275 (estimated)
       No. of Industries: 6
       No. of Occupations: 23
       No. of Employees: 5131 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 82995
       No. of Facilities: 6941 (estimated)
       No. of Industries: 70
       No. of Occupations: 72
       No. of Employees: 150745 (estimated)
       No. of Female Employees: 36237 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***