*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : PB0825900
CHEMICAL NAME           : Methanesulfonanilide,
                          4'-(1-hydroxy-2-(isopropylamino)ethyl)-
CAS REGISTRY NUMBER     : 3930-20-9
LAST UPDATED            : 199806
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C12-H20-N2-O3-S
MOLECULAR WEIGHT        : 272.40
WISWESSER LINE NOTATION : WS1&MR DYQ1MY1&1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * beta-Cardone
   * Methanesulfonamide,  
   N-(4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)phenyl)-
   * Sotalol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 118 mg/kg/4W-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Cardiac - pulse rate
   Cardiac - change in rate
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 68,289,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 3429 ug/kg/2D-I
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Cardiac - pulse rate
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ANZJB8 Australian and New Zealand Journal of Medicine.  (Modern Medicine of
   Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia)
   V.1-    1971-  Volume(issue)/page/year: 24,319,1994
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 288 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - change in rate
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   26,389,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 14 mg/kg/3D-I
TOXIC EFFECTS :
   Cardiac - pulse rate increase, without fall in BP
   Cardiac - pulse rate
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   ANZJB8 Australian and New Zealand Journal of Medicine.  (Modern Medicine of
   Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia)
   V.1-    1971-  Volume(issue)/page/year: 24,319,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Multiple routes
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 100 mg/kg/2W-I
TOXIC EFFECTS :
   Cardiac - other changes
REFERENCE :
   AHJOA2 American Heart Journal.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63146) V.1-    1925-  Volume(issue)/page/year:
   107,179,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 790 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   25,145,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 113 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #5179095
 
                            *** END OF RECORD ***