*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : PB1800000 CHEMICAL NAME : Methanesulfonic acid, 2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl ester CAS REGISTRY NUMBER : 61866-12-4 LAST UPDATED : 198806 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C5-H10-Cl-N3-O5-S MOLECULAR WEIGHT : 259.69 WISWESSER LINE NOTATION : WS1&O1MVNNO&2G COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * 2-(3-(2-Chlorathyl)-3-nitrosoureido)athylmethansulfonat * 2-(3-(2-Chloroethyl)3-nitrosoureido)ethyl methane sulfonate * Cnuems * Ethylmethanesulfonato-cnu * NSC-294896 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : VDGIA2 Verhandlungen der Deutschen Gesellschaft fuer Innere Medizin. (J.F. Bergmann Verlag, Agnes-Bernauer-Platz 8, D-8000 Munich 21, Fed. Rep. Ger.) V.33-52, 1921-40; V.54- 1948- Volume(issue)/page/year: 85,1293,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 13800 ug/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - ulceration or bleeding from stomach Blood - changes in bone marrow (not otherwise specified) REFERENCE : ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 37,177,1980 ** MUTATION DATA ** TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 500 umol/L/16H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,45,1977 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion *** END OF RECORD ***