*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PA6390000
CHEMICAL NAME : Methane, chlorodifluoro-
CAS REGISTRY NUMBER : 75-45-6
BEILSTEIN REFERENCE NO. : 1731036
REFERENCE : 4-01-00-00032 (Beilstein Handbook Reference)
LAST UPDATED : 199712
DATA ITEMS CITED : 44
MOLECULAR FORMULA : C-H-Cl-F2
MOLECULAR WEIGHT : 86.47
WISWESSER LINE NOTATION : GYFF
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Algeon 22
* Algofrene 22
* Algofrene type 6
* Arcton 4
* Arcton 22
* CFC 22
* Chlorodifluoromethane
* Daiflon 22
* Difluorochloromethane
* Difluoromonochloromethane
* Dymel 22
* Electro-CF 22
* Eskimon 22
* F 22
* Flugene 22
* Fluorocarbon-22
* Forane 22
* Freon 22
* Frigen 22
* Genetron 22
* Haltron 22
* HFA-22
* Isceon 22
* Isotron 22
* Khaladon 22
* Monochlorodifluoromethane
* Propellant 22
* R-22
* R 22 (refrigerant)
* Racon 22
* Refrigerant R 22
* Ucon 22
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >43200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 48(8),69,1983
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 35 pph/15M
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke,
Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 1,239,1982
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1380 mg/m3/2H
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
Volume(issue)/page/year: 75,241,1963
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 70 pph
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
2,363,1960
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 30 pph/2H
TOXIC EFFECTS :
Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed.
Rep. Ger.) V.1-25, 1951-75. Volume(issue)/page/year: 21,149,1971
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2457 mg/kg/26W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - changes in other cell count (unspecified)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 48(8),69,1983
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 gm/m3/6H/43W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Spinal Cord - other degenerative changes
Behavioral - alteration of classical conditioning
REFERENCE :
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
Volume(issue)/page/year: 75,231,1963
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 50000 ppm/5H
SEX/DURATION : male 56 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
1,266,1981
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 5 ppm
SEX/DURATION : female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0520838
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 33 pph/24H (Continuous)
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 2,1,1978
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 3540 mg/m3 (1000 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 41,237,1986
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 41,237,1986
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,149,1987
TOXICOLOGY REVIEW
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research.
(Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974
TOXICOLOGY REVIEW
NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of
New York, POB 5405, Lake Success, NY 11042) V.1- 1901-
Volume(issue)/page/year: 74,1939,1974
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993
OEL-AUSTRIA:TWA 500 ppm (1800 mg/m3) JAN 1993
OEL-BELGIUM:TWA 1000 ppm (3540 mg/m3);STEL 1250 ppm JAN 1993
OEL-DENMARK:TWA 1000 ppm (3500 mg/m3) JAN 1993
OEL-FINLAND:TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993
OEL-FRANCE:TWA 1000 ppm (3500 mg/m3) JAN 1993
OEL-GERMANY:TWA 500 ppm (1800 mg/m3) JAN 1993
OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993
OEL-JAPAN:TWA 1000 ppm (3500 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 1000 ppm (3500 mg/m3) JAN 1993
OEL-RUSSIA:TWA 1000 ppm;STEL 3000 mg/m3 JAN 1993
OEL-SWEDEN:TWA 500 ppm (1800 mg/m3);STEL 750 ppm (2500 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 500 ppm (1800 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1000 ppm (3500 mg/m3);STEL 1250 ppm JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO CHLORODIFLUOROMETHANE-air:TWA 1000 ppm;STEL 1250 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 80048
No. of Facilities: 7420 (estimated)
No. of Industries: 76
No. of Occupations: 44
No. of Employees: 56234 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 80048
No. of Facilities: 12513 (estimated)
No. of Industries: 78
No. of Occupations: 57
No. of Employees: 157080 (estimated)
No. of Female Employees: 12185 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9099;8EHQ-0892-9107
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9108;8EHQ-0892-9117
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9118
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Chlorodifluoromethane, 1018
*** END OF RECORD ***