*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PA2275000
CHEMICAL NAME : Methanearsonic acid, disodium salt
CAS REGISTRY NUMBER : 144-21-8
LAST UPDATED : 199707
DATA ITEMS CITED : 36
MOLECULAR FORMULA : C-H3-As-O3.2Na
MOLECULAR WEIGHT : 183.94
WISWESSER LINE NOTATION : Q-AS-QO&1 &-NA- 2
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Ansar 184
* Ansar 8100
* Ansar DSMA Liquid
* Arrhenal
* Arsinyl
* Arsonic acid, methyl-, disodium salt
* Arsynal
* Cacodyl New
* Chipco Crab Kleen
* Crab-3-rad 100
* Cralo-E-rad
* Dal-E-Rad 100
* Diarsen
* Disodium methanearsonate
* Disodium methylarsonate
* Disodium monomethylarsonate
* Disomear
* Di-tac
* DMA 100
* DSMA
* Jon-trol
* Methar
* Methar 30
* Metharsan
* Metharsinat
* Methylarsonat disodny
* Neo-Asycodile
* Sodar
* Somar
* Stenosine
* Tonarsan
* Tonarsin
* Versar DSMA LQ
* Weed broom
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 821 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
7,299,1986
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >22100 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C119,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc.,
1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For
publisher information, see AGJAEP. Volume(issue)/page/year: (3),5,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: AD691-490
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave.,
Willoughy, OH 44094) Volume(issue)/page/year: -,C119,1991
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE : 600 mg/kg
SEX/DURATION : female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 25(2),50A,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - hamster
DOSE : 500 mg/kg
SEX/DURATION : female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 29,679,1982
*** REVIEWS ***
TOXICOLOGY REVIEW
JORCAI Journal of Organometallic Chemistry. (Elsevier Sequoia SA, POB 851,
CH-1001 Lausanne l, Switzerland) V.1- 1963- Volume(issue)/page/year:
76,265,1974
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: As,-,1977
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 0.5 mg(As)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,16,1971
OSHA PEL (Gen Indu):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.5 mg(As)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993
OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993
OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993
OEL-DENMARK:TWA 0.05 mg(As)/m3 JAN 1993
OEL-FINLAND;Carcinogen JAN 1993
OEL-FRANCE:TWA 0.2 mg(As)/m3 JAN 1993
OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993
OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993
OEL-POLAND:TWA 0.3 mg(As)/m3 JAN 1993
OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993
OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993
OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP
reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
*** END OF RECORD ***