*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : PA8200000
CHEMICAL NAME           : Methane, dichlorodifluoro-
CAS REGISTRY NUMBER     : 75-71-8
LAST UPDATED            : 199712
DATA ITEMS CITED        : 49
MOLECULAR FORMULA       : C-Cl2-F2
MOLECULAR WEIGHT        : 120.91
WISWESSER LINE NOTATION : GXGFF
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * Algofrene type 2
   * Arcton 6
   * Arcton 12
   * CFC 12
   * Chlorofluorocarbon 12
   * Dichlorodifluoromethane
   * Difluorodichloromethane
   * Dwuchlorodwufluorometan
   * Dymel 12
   * Electro-CF 12
   * F 12
   * FC 12
   * FCC 12
   * FKW 12
   * Fluorocarbon-12
   * Forane 12
   * Freon 12
   * Eskimon 12
   * Freon F-12
   * Frigen 12
   * Genetron 12
   * Isceon 122
   * Isotron 12
   * Kaiser chemicals 12
   * Ledon 12
   * Propellant 12
   * RCRA waste number U075
   * R 12 (refrigerant)
   * Refrigerant R 12
   * Ucon 12
   * Ucon 12/halocarbon 12
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 200000 ppm/30M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - conjunctive irritation
   Lungs, Thorax, or Respiration - fibrosing alveolitis
   Liver - other changes
REFERENCE :
   EJTXAZ European Journal of Toxicology and Environmental Hygiene.  (Paris,
   France)  V.7-9, 1974-76. For publisher information, see TOERD9.
   Volume(issue)/page/year: 9,385,1976
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 52(3),73,1987
 
TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >80 pph/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0520424
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3348 gm/m3/3H
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - tremor
   Behavioral - excitement
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 28(6),95,1963
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 80 pph/30M
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJTXAZ European Journal of Toxicology and Environmental Hygiene.  (Paris,
   France)  V.7-9, 1974-76. For publisher information, see TOERD9.
   Volume(issue)/page/year: 9,385,1976
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 80 pph/30M
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJTXAZ European Journal of Toxicology and Environmental Hygiene.  (Paris,
   France)  V.7-9, 1974-76. For publisher information, see TOERD9.
   Volume(issue)/page/year: 9,385,1976
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2548 mg/kg/26W-I
TOXIC EFFECTS :
   Behavioral - alteration of classical conditioning
   Blood - changes in erythrocyte (RBC) count
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 52(3),73,1987
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4136 mg/m3/8H/6W-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   10,270,1967
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3997 mg/m3/90D-C
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   10,270,1967
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 3997 mg/m3/90D-C
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   10,270,1967
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3997 mg/m3/90D-C
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   10,270,1967
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 3997 mg/m3/90D-C
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   10,270,1967

                              *** REVIEWS ***
 
   ACGIH TLV-Not classifiable as a human carcinogen
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   ACGIH TLV-TWA 4950 mg/m3 (1000 ppm)
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   TOXICOLOGY REVIEW
   FAZMAE Fortschritte der Arzneimittelforschung.  Progress in Drug Research.
   (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
   Secaucus, NJ 07094)  V.1-    1959-  Volume(issue)/page/year: 18,365,1974

   TOXICOLOGY REVIEW
   NYSJAM New York State Journal of Medicine.  (Medical Soc. of the State of
   New York, POB 5405, Lake Success, NY 11042)  V.1-    1901-
   Volume(issue)/page/year: 74,1939,1974

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
   FEREAC Federal Register.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402) V.1-    1936-  Volume(issue)/page/year:
   54,7740,1989

   MSHA STANDARD-air:TWA 1000 ppm (4950 mg/m3)
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year: 3,78,1971

   OSHA PEL (Gen Indu):8H TWA 1000 ppm (4950 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 1000 ppm (4950 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 1000 ppm (4950 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 1000 ppm (4950 mg/m3)
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-AUSTRALIA:TWA 1000 ppm (4950 mg/m3) JAN 1993
   
   OEL-AUSTRIA:TWA 1000 ppm (5000 mg/m3) JAN 1993
   
   OEL-BELGIUM:TWA 1000 ppm (4950 mg/m3) JAN 1993
   
   OEL-DENMARK:TWA 1000 ppm (4950 mg/m3) JAN 1993
   
   OEL-FINLAND:TWA 1000 ppm (4950 mg/m3);STEL 1250 ppm (6200 mg/m3) JAN 1993
   
   OEL-FRANCE:TWA 1000 ppm (4950 mg/m3) JAN 1993
   
   OEL-GERMANY:TWA 1000 ppm (5000 mg/m3) JAN 1993
   
   OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993
   
   OEL-JAPAN:TWA 500 ppm (2500 mg/m3) JAN 1993
   
   OEL-THE NETHERLANDS:TWA 1000 ppm (4950 mg/m3) JAN 1993
   
   OEL-THE PHILIPPINES:TWA 1000 ppm (4950 mg/m3) JAN 1993
   
   OEL-POLAND:TWA 4000 mg/m3 JAN 1993
   
   OEL-RUSSIA:TWA 500 ppm;STEL 3000 mg/m3 JAN 1993
   
   OEL-SWEDEN:TWA 500 ppm (2500 mg/m3);STEL 750 ppm (4000 mg/m3) JAN 1993
   
   OEL-SWITZERLAND:TWA 1000 ppm (5000 mg/m3) JAN 1993
   
   OEL-TURKEY:TWA 1000 ppm (4950 mg/m3) JAN 1993
   
   OEL-UNITED KINGDOM:TWA 1000 ppm (4950 mg/m3);STEL 1250 ppm JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO DICHLORODIFLUOROMETHANE-air:10H TWA 1000 ppm
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 24095
       No. of Facilities: 139220 (estimated)
       No. of Industries: 403
       No. of Occupations: 213
       No. of Employees: 1892483 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 24095
       No. of Facilities: 30739 (estimated)
       No. of Industries: 177
       No. of Occupations: 140
       No. of Employees: 510790 (estimated)
       No. of Female Employees: 143439 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   On EPA IRIS database
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NIOSH Analytical Method, 1994: Dichlorodifluoromethane, 1018

 
                            *** END OF RECORD ***