*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : PB9268200
CHEMICAL NAME           : 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthen
                          e-1-crotonic acid, 3a,4,5,7-tetrahydro-
                          8-hydroxy-alpha,3,3,11-tetramethyl-13-(3-methyl-2-but
                          enyl)-11-(4-methyl-3- pentenyl)-7,15- dioxo-, (Z)-
CAS REGISTRY NUMBER     : 2752-65-0
LAST UPDATED            : 199503
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C38-H44-O8
MOLECULAR WEIGHT        : 628.82
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Cambogic acid
   * beta-Guttiferin
   * B''-Guttiferin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 88 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 5,96,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 107 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 5,96,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 354 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 8(1),331,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85PEAG "Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai
   Science/Technology Publisher, Peop. Rep. China, 1994
   Volume(issue)/page/year: -,220,1994
 
                            *** END OF RECORD ***