*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PC5150000
CHEMICAL NAME : 3,6-Methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)
azulene-4,8(3H)-dione, hexahydro-
2a-hydroxy-8b-methyl-9-(1-methylethenyl)-,
(1aR-(1a-alpha,2a-beta,3-beta,6-beta,6a-beta,
8as*,8b-beta,9R*))-
CAS REGISTRY NUMBER : 17617-45-7
LAST UPDATED : 199806
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C15-H16-O6
MOLECULAR WEIGHT : 292.31
SYNONYMS/TRADE NAMES :
* Picrotoxinin
* Picrotoxinine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8980 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho
Turnpike, Suite 207, Commack, NY 11725) V.1 1993-
Volume(issue)/page/year: 1,199,1993
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1600 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPHAA3 Journal of the American Pharmaceutical Association. (Washington, DC)
V.1-28, 1912-39; New series: V.1-17, 1961-77. Volume(issue)/page/year:
23,98,1934
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 60,289,1992
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation,"
Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed.
Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1350 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation,"
Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed.
Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 1600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation,"
Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed.
Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 1600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPHAA3 Journal of the American Pharmaceutical Association. (Washington, DC)
V.1-28, 1912-39; New series: V.1-17, 1961-77. Volume(issue)/page/year:
23,98,1934
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 1100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation,"
Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed.
Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931
*** END OF RECORD ***