*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : PD0457000 CHEMICAL NAME : Methionine, L- CAS REGISTRY NUMBER : 63-68-3 LAST UPDATED : 199710 DATA ITEMS CITED : 24 MOLECULAR FORMULA : C5-H11-N-O2-S MOLECULAR WEIGHT : 149.23 WISWESSER LINE NOTATION : QVYZ2S1 -L COMPOUND DESCRIPTOR : Mutagen Reproductive Effector SYNONYMS/TRADE NAMES : * L-alpha-Amino-gamma-methylmercaptobutyric acid * (S)-2-Amino-4-(methylthio)butanoic acid * L(-)-Amino-gamma-methylthiobutyric acid * 2-Amino-4-methylthiobutanoic acid * 2-Amino-4-(methylthio)butyric acid * Butyric acid, 2-amino-4-(methylthio)- * Butanoic acid, 2-amino-4-(methylthio)-, (S)- * Cymethion * Lactet * Liquimeth * Methionine * L-Methionine * L-(-)-Methionine * S-Methionine * L-gamma-Methylthio-alpha-aminobutyric acid *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 36 gm/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Immunological Including Allergic - uncharacterized REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(6),20,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4328 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease REFERENCE : ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 58,253,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >9500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,682,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 21600 mg/kg/60D-I TOXIC EFFECTS : Liver - changes in liver weight Blood - leukopenia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 48(6),20,1983 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 26100 mg/kg SEX/DURATION : female 10-20 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 82,457,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 14720 mg/kg SEX/DURATION : female 10-20 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 82,457,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 35 gm/kg SEX/DURATION : female 2 week(s) pre-mating female 1-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 46,499,1992 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 100 mg/L REFERENCE : PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,376,1981 TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 200 mg/L REFERENCE : PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,224,1981 TYPE OF TEST : DNA repair TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 500 mg/L REFERENCE : PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,502,1981 TYPE OF TEST : DNA damage TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 2 umol/L REFERENCE : BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year: 696,15,1982 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Fibroblast DOSE/DURATION : 125 mg/L REFERENCE : PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,517,1981 TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 10 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 2 umol/L REFERENCE : BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year: 696,15,1982 TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - guinea pig DOSE/DURATION : 500 mg/kg REFERENCE : JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 47,190a,1970 *** REVIEWS *** TOXICOLOGY REVIEW JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 22,2,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81891 No. of Facilities: 273 (estimated) No. of Industries: 5 No. of Occupations: 17 No. of Employees: 12017 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81891 No. of Facilities: 1116 (estimated) No. of Industries: 4 No. of Occupations: 18 No. of Employees: 28520 (estimated) No. of Female Employees: 17038 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 *** END OF RECORD ***