*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : PD0520000
CHEMICAL NAME           : L-Methionine,
                          N-(3-(bis(2-chloroethyl)amino)-N-(4-fluoro-L-phenylal
                          anyl)-L-phenylalanyl) -, ethyl ester,
                          monohydrochloride
CAS REGISTRY NUMBER     : 83996-50-3
LAST UPDATED            : 199512
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C29-H39-Cl2-F-N4-O4-S.Cl-H
MOLECULAR WEIGHT        : 666.14
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * PT 119
   * PTT 119
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9200 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 38,205,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9300 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 38,205,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 38,205,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 38,205,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 3670 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - food intake (animal)
   Blood - other changes
REFERENCE :
   FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
   V.8-43    1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 40,242,1985
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 3200 ug/kg/4W-I
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy)
   V.8-43    1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 40,242,1985
 
                            *** END OF RECORD ***