*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : PY8030000
CHEMICAL NAME : Mineral oil
CAS REGISTRY NUMBER : 8012-95-1
OTHER CAS REGISTRY NOS. : 39355-35-6
79956-36-8
83046-05-3
LAST UPDATED : 199712
DATA ITEMS CITED : 42
COMPOUND DESCRIPTOR : Tumorigen
Human
Primary Irritant
SYNONYMS/TRADE NAMES :
* Adepsine oil
* Alboline
* Bayol 55
* Bayol F
* Blandlube
* Crystol 325
* Crystosol
* Glymol
* Kondremul
* Liquid paraffin
* Neo-cultol
* Nujol
* Oil mist, mineral
* Paraffin oil
* Paroleine
* Petrogalar
* Primol 355
* Primol D
* Saxol
* USP mineral oil
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL
60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg
REACTION SEVERITY : Moderate
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
Volume(issue)/page/year: 29,1363,1946
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 100 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL
60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 22 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74.
For publisher information, see ARTODN. Volume(issue)/page/year:
30,243,1973
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5200 uL/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3340
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20800 uL/kg/13W-I
TOXIC EFFECTS :
Liver - changes in liver weight
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-92-3340
** TUMORIGENIC DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - man
DOSE/DURATION : 5 mg/m3/5Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational
Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
Volume(issue)/page/year: 23,333,1981
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 332 gm/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Skin and Appendages - tumors
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of
Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
Volume(issue)/page/year: 132,439,1965
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 14 gm/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - leukemia
Lungs, Thorax, or Respiration - bronchiogenic carcinoma
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 193,1086,1962
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 60 gm/kg/17W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,703,1978
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 60 gm/kg/17W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
REFERENCE :
IMMUAM Immunology. (Blackwell Scientific Pub., 52 Beacon St., Boston, MA
02108) V.1- 1958- Volume(issue)/page/year: 17,481,1969
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 gm/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - tumors
Immunological Including Allergic - decreased immune response
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 6,422,1970
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 72 gm/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Blood - tumors
REFERENCE :
JOIMA3 Journal of Immunology. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1916- Volume(issue)/page/year: 92,747,1962
*** REVIEWS ***
ACGIH TLV-STEL 10 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 5 mg/m3 (non-vapor sampling)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
PAASAH Publication of the American Association for the Advancement of
Science. (Washington, DC) No.1-94, 1934-73. Discontinued.
Volume(issue)/page/year: 54,171,1959
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 5 mg/m3 (particulate)
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,25,1973
OSHA PEL (Gen Indu):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 5 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993
OEL-BELGIUM:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993
OEL-DENMARK:TWA 2 mg/m3 JAN 1993
OEL-FINLAND:TWA 5 mg/m3 JAN 1993
OEL-HUNGARY:STEL 5 mg/m3;Carcinogen JAN 1993
OEL-JAPAN:TWA 3 mg/m3 JAN 1993
OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993
OEL-RUSSIA:STEL 5 mg/m3 JAN 1993
OEL-SWEDEN:TWA 3 mg/m3 JAN 1993
OEL-SWEDEN:TWA 3 mg/m3;STEL 5 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - T1542
No. of Facilities: 22 (estimated)
No. of Industries: 3
No. of Occupations: 7
No. of Employees: 698 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - T1542
No. of Facilities: 49328 (estimated)
No. of Industries: 275
No. of Occupations: 178
No. of Employees: 1100229 (estimated)
No. of Female Employees: 433405 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Oil mist, mineral, 5026
*** END OF RECORD ***