*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QC8590000
CHEMICAL NAME           : Morphinan-3,6-alpha-diol,
                          7,8-didehydro-4,5-alpha-epoxy-17-methyl-,
                          hydrochloride, trihydrate
CAS REGISTRY NUMBER     : 6055-06-7
LAST UPDATED            : 199209
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C17-H19-N-O3.Cl-H.3H2-O
MOLECULAR WEIGHT        : 375.89
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 7,8-Didehydro-4,5-alpha-epoxy-17-methylmorphinan-3,6-alpha-diol  
   hydrochloride trihydrate
   * Morphine hydrochloride trihydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 335 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 23,93,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 112,191,1954
 
                            *** END OF RECORD ***