*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QC8640000
CHEMICAL NAME           : Morphinan-3,6-alpha-diol,
                          7,8-didehydro-4,5-alpha-epoxy-17-methyl-, 17-oxide
CAS REGISTRY NUMBER     : 639-46-3
LAST UPDATED            : 199306
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C17-H19-N-O4
MOLECULAR WEIGHT        : 301.37
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Genomorphin
   * Genomorphine
   * Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-,  
   (5-alpha,6-alpha)-, 17-oxide
   * Morphine oxide
   * Morphine N-oxide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 21,668,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 820 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 21,668,1969
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22 gm/kg/22D-I
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 21,668,1969
 
                            *** END OF RECORD ***