*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QD2181500
CHEMICAL NAME           : Morphinan-6-one,
                          3,14-dihydroxy-4,5-alpha-epoxy-17-methyl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 357-07-3
LAST UPDATED            : 198910
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C17-H19-N-O4.Cl-H
MOLECULAR WEIGHT        : 337.83
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 4,5-alpha-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one hydrochloride
   * Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-methyl-, hydrochloride,  
   (5-alpha)-
   * Numorphan hydrochloride
   * Oxymorphinone hydrochloride
   * Oxymorphone hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 402 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 15,1208,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 301 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 15,1208,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 285 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 15,1208,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 185 mg/kg
TOXIC EFFECTS :
   Behavioral - analgesia
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 15,1208,1960
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 172 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 123,705,1975
 
                            *** END OF RECORD ***