*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QD2840000
CHEMICAL NAME           : Morphinan-6-one,
                          4,5-alpha-epoxy-3-methoxy-17-methyl-, tartrate (1:1)
CAS REGISTRY NUMBER     : 34195-34-1
LAST UPDATED            : 199504
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C18-H21-N-O3.C4-H6-O6
MOLECULAR WEIGHT        : 449.50
WISWESSER LINE NOTATION : T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JO1 P1
                          &OVYQYQVO
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Codeinone, dihydro-, tartrate
   * Dihydrocodeinone bitartrate
   * Hydrocodone bitartrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 375 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   1,42,1959
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 153 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 123,705,1975

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80428
       No. of Facilities: 2327 (estimated)
       No. of Industries: 3
       No. of Occupations: 8
       No. of Employees: 9115 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80428
       No. of Facilities: 162 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 2238 (estimated)
       No. of Female Employees: 1177 (estimated)

 
                            *** END OF RECORD ***