*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QD3181000
CHEMICAL NAME           : Morphinan-3,6-alpha,14-triol,
                          17-(cyclobutylmethyl)-4,5-alpha-epoxy-, hydrochloride
CAS REGISTRY NUMBER     : 23277-43-2
LAST UPDATED            : 199504
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C21-H27-N-O4.Cl-H
MOLECULAR WEIGHT        : 393.95
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 17-Cyclobutylmethyl-4,5-alpha-epoxymorphinan-3,6-alpha,14-triol  
   hydrochloride
   * N-Cyclobutylmethyl-14-hydroxydihydronormorphine hydrochloride
   * En 2234A
   * Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, hydrochloride,  
   (5-alpha,6-alpha)-
   * Nalbufina clorhidrato
   * Nalbuphine hydrochloride
   * Nubain
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 800 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   CHETBF Chest.  (American College of Chest Physicians, 911 Busse Hwy, Park
   Ridge, IL 60068) V.57-    1970-  Volume(issue)/page/year: 90,773,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   16,51,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   16,51,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   16,51,1980

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5314
       No. of Facilities: 7 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 628 (estimated)
       No. of Female Employees: 314 (estimated)

 
                            *** END OF RECORD ***