*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QD8750000
CHEMICAL NAME           : Morpholine, 4-(3-(p-butoxyphenoxy)propyl)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 637-58-1
LAST UPDATED            : 199504
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C17-H27-N-O3.Cl-H
MOLECULAR WEIGHT        : 329.91
WISWESSER LINE NOTATION : T6N DOTJ A3OR DO4 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-(3-(p-Butoxyphenoxy)propyl)-morpholine hydrochloride
   * p-Butoxyphenyl gamma-morpholinopropyl ether hydrochloride
   * gamma-Morpholinopropyl 4-n-butoxyphenyl ether hydrochloride
   * Pramoxine hydrochloride
   * Proctofoam
   * Tronothane hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1050 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,99,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,99,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1470 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - cardiac output
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AAREAV Anesthesie, Analgesie, Reanimation.  (Paris, France)  V.14-38,
   1957-81.  Volume(issue)/page/year: 14,225,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 79500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   1,454,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 39 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,99,1969
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 109 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - cardiac output
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AAREAV Anesthesie, Analgesie, Reanimation.  (Paris, France)  V.14-38,
   1957-81.  Volume(issue)/page/year: 14,225,1957

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 80493
       No. of Facilities: 68 (estimated)
       No. of Industries: 1
       No. of Occupations: 6
       No. of Employees: 2770 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 80493
       No. of Facilities: 98 (estimated)
       No. of Industries: 2
       No. of Occupations: 11
       No. of Employees: 16892 (estimated)
       No. of Female Employees: 15582 (estimated)

 
                            *** END OF RECORD ***