*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : QE3477835 CHEMICAL NAME : 4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride CAS REGISTRY NUMBER : 25953-17-7 LAST UPDATED : 199707 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C17-H22-N4-O.2Cl-H MOLECULAR WEIGHT : 371.35 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * AG 620 * AGR 620 * AGR 1240 * Cantor * 30038CM * N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine dihydrochloride * Minaprine dihydrochloride * Morpholine, 4-(2-((4-methyl-6-phenyl-3-pyridazinyl)amino)ethyl)-, dihydrochloride * 3-(2-Morpholinoethylamino)-4-methyl-6-phenylpyridazine dihydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >100 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,824,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 63 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4508720 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4823 mg/kg/13W-I TOXIC EFFECTS : Endocrine - changes in adrenal weight Endocrine - changes in thymus weight REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,1894,1990 *** END OF RECORD ***