*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QE9470000
CHEMICAL NAME           : Morpholine, 4,4-selenodiethylenebis-, dihydrochloride
LAST UPDATED            : 199712
DATA ITEMS CITED        : 23
MOLECULAR FORMULA       : C12-H24-N2-O2-Se.2Cl-H
MOLECULAR WEIGHT        : 380.26
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Bis(beta-(N,N-dimorpholino)ethyl)selenide dihydrochloride
   * MOSE
   * 4,4'-(Selenodi-2,1-ethanediyl)bismorpholine dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 7,41,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1250 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 7,41,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 7,41,1984

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 0.2 mg(Se)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.2 mg(Se)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year: 3,16,1971

   OSHA PEL (Gen Indu):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 0.2 mg(Se)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-ARAB Republic of Egypt:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-AUSTRALIA:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-BELGIUM:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-DENMARK:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-FINLAND:TWA 0.1 mg(Se)/m3;STEL 0.3 mg(Se)/m3 JAN 1993
   
   OEL-GERMANY:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-HUNGARY:STEL 0.1 mg(Se)/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-POLAND:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 0.1 mg(Se)/m3 JAN 1993
   
   OEL-TURKEY:TWA 0.2 mg(Se)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.1 mg(Se)/m3 JAN 1993

 
                            *** END OF RECORD ***