*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QF1790000
CHEMICAL NAME           : Morpholine, 4-(3,4,5-trimethoxythiobenzoyl)-
CAS REGISTRY NUMBER     : 35619-65-9
BEILSTEIN REFERENCE NO. : 1222876
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C14-H19-N-O4-S
MOLECULAR WEIGHT        : 297.40
WISWESSER LINE NOTATION : T6N DOTJ AYUS&R CO1 DO1 EO1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * ISF 2001
   * Morpholine, 4-(thioxo(3,4,5-trimethoxyphenyl)methyl)-
   * 4-(Thioxo(3,4,5-trimethoxyphenyl)methyl)morpholine
   * Tresanil
   * Trithiozine
   * 4-(3,4,5-Trimethoxythiobenzoyl)morpholine
   * 4-(3,4,5-Trimethoxythiobenzoyl)tetrahydro-1,4-oxazine
   * Tritiozina
   * Tritiozine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 670 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 38,811,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   32VRA9 Proceedings of the International Congress of Pharmacology, 6th,
   Helsinki, July 20-25, 1975," Tuomisto, J., and M.K. Paasonen, eds.,
   (Pergamon Press Ltd., Headington Hill Hall, Oxford, OX3 OBW, UK) 1976
   Volume(issue)/page/year: 6,68,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - alteration in gastric secretion
REFERENCE :
   CHTPBA Chimica Therapeutica.  (Paris, France)  V.1-8, 1965-73.  For
   publisher information, see EJMCA5.  Volume(issue)/page/year: 8,462,1973
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 13500 mg/kg
SEX/DURATION            : female 15-22 day(s) after conception
                          lactating female 20 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 4,284,1980
 
                            *** END OF RECORD ***