*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QG2000000
CHEMICAL NAME           : Murine recombinant interleukin-2
LAST UPDATED            : 199503
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * IL-2
   * Interleukin-2, murine recombinant
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5600 ug/kg/2W-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Blood - leukopenia
   Related to Chronic Data - changes in testicular weight
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 14,219,1994
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 6 ku/kg
SEX/DURATION            : female 6-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 89,447,1990
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 50 units/mL
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   15,10,1990
 
                            *** END OF RECORD ***