*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QI7830000
CHEMICAL NAME : 2-Naphthacenecarboxamide,
7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octah
ydro-
3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-
CAS REGISTRY NUMBER : 2013-58-3
LAST UPDATED : 198803
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C22-H21-Cl-N2-O8
MOLECULAR WEIGHT : 476.90
SYNONYMS/TRADE NAMES :
* 7-Chloro-6-methylene-5-oxytetracycline
* 7-Cloro-6-metilene-5-ossitetraciclina
* GS 2989
* Meclociclina
* Meclocycline
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,1022,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,1022,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 425 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GICTAL Giornale Italiano di Chemioterapia. Italian Journal of Chemotherapy.
(Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1-
1954- Volume(issue)/page/year: 17,276,1970
*** END OF RECORD ***