*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9160000
CHEMICAL NAME           : 2-Naphthacenecarboxamide,
                          4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-
                          3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-p
                          yrrolidinylmethyl)-, mononitrate (salt)
CAS REGISTRY NUMBER     : 20685-78-3
LAST UPDATED            : 199309
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C27-H33-N3-O8.H-N-O3
MOLECULAR WEIGHT        : 590.65
WISWESSER LINE NOTATION : L E6 C666 BV FV CU GUTTT&J DQ EQ HQ MQ M1 RQ GVM2-
                          AT5NTJ &..H..N-O3
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Bristacin-A
   * Pyrrocycline N
   * Rolitetracycline nitrate
   * Syntetrin nitrate
   * Tetrex PMT
   * Tetrim
   * Tetriv
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 91 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,915,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 431 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,915,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 274 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,915,1982
 
                            *** END OF RECORD ***