*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9277540
CHEMICAL NAME           : 2-Naphthacenecarboxamide,
                          1,4,4a,5,12,12a-hexahydro-4-(dimethylamino)-1,12-diox
                          o-6-methyl- 3,10,11,12a-tetrahydroxy-, 4-epimer
CAS REGISTRY NUMBER     : 1665-57-2
LAST UPDATED            : 199009
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C22-H22-N2-O7
MOLECULAR WEIGHT        : 426.46
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-epi-Anhydrotetracycline
   * Epianhydrotetracycline
   * 4-Epianhydrotetracycline
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 193 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YHHPAL Yaoxue Xuebao.  Acta Pharmaceutica Sinica.  Pharmaceutical Journal.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  V.1-    1953-    Suspended 1966-78.  Volume(issue)/page/year:
   13,244,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 29200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
   In New Drugs, Proceedings of the Symposium on Toxicological Testing for
   Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
   Czechoslovakia, Univerzita Karlova, 1979  Volume(issue)/page/year: -,55,1979
 
                            *** END OF RECORD ***