*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9296050
CHEMICAL NAME           : 5,12-Naphthacenedione,
                          10-(((2''',3''-anhydro)-O-3,6-dideoxy-alpha-L-erythro
                          -hexopyranos-4-
                          ulosyl-(1-4)-O-2,6-dideoxy-alpha-L-lyxo-hexopyranosyl
                          -(1-4)-2,3,6-trideoxy -3-(dimethylamino)-
                          alpha-L-lyxo-hexopyranosyl)oxy)-8-ethyl-7,8,9,10-tetr
                          ahydro-1,6,8,11-tetra hydroxy-7-((2,3,6-
                          trideoxy-4-O-(2,6-dideoxy-4-O-((2R-trans)-tetrahydro-
                          6-methyl-5-oxo-2H-pyr an-2-yl)-alpha-L-
                          lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-L-lyxo-he
                          xopyranosyl)oxy)-, (7R-(7-alpha,8-beta, 10-beta))-
CAS REGISTRY NUMBER     : 87399-21-1
LAST UPDATED            : 199307
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C60-H82-N2-O22
MOLECULAR WEIGHT        : 1183.44
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Ditrisarubicin A
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 36,1080,1983
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 310 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 36,1080,1983
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 23 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 36,1080,1983
 
                            *** END OF RECORD ***