*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9296070
CHEMICAL NAME           : 5,12-Naphthacenedione,
                          10-(((2''',3''-anhydro)-O-3,6-dideoxy-alpha-L-erythro
                          -hexopyranos-4-
                          ulosyl-(1-4)-O-2,6-dideoxy-alpha-L-lyxo-hexopyranosyl
                          -(1-4)-2,3,6-trideoxy -3-(dimethylamino)-
                          alpha-L-lyxo-hexopyranosyl)oxy)-8-ethyl-7,8,9,10-tetr
                          ahydro-1,6,8,11-tetra hydroxy-7-((2,3,6-
                          trideoxy-4-O-((2S-(2-alpha,5-beta(2S*,6R*),6-beta))-5
                          -((5,6-dihydro-6-meth yl-5-oxo-2H-pyran-
                          2-yl)oxy)tetrahydro-6-methyl-2H-pyran-2-yl)-3-(dimeth
                          ylamino)-alpha-L-lyxo -hexopyranosyl) oxy)-,
                          (7R-(7-alpha,8-beta,10-beta))-
CAS REGISTRY NUMBER     : 87385-18-0
LAST UPDATED            : 199307
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C60-H80-N2-O21
MOLECULAR WEIGHT        : 1165.42
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Ditrisarubicin C
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 36,1080,1983
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 140 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 36,1080,1983
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 14 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 36,1080,1983
 
                            *** END OF RECORD ***