*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9423100
CHEMICAL NAME           : 5,12-Naphthacenedione,
                          7,8,9,10-tetrahydro-8-ethyl-10-((3-(4-morpholinyl)-2,
                          3,6-
                          trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,6,7,8,11-p
                          entahydroxy-, hydrochloride,
                          (7R-(7-alpha,8-beta,10-beta))-
CAS REGISTRY NUMBER     : 131722-57-1
LAST UPDATED            : 199212
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C30-H35-N-O11.Cl-H
MOLECULAR WEIGHT        : 622.12
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 3'-Deamino-3'-morpholino-13-deoxo-10-hydroxycarminomycin hydrochloride
   * KRN 8602
   * MX2 hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Blood - hemorrhage
REFERENCE :
   GTKRDX Gan to Kagaku Ryoho.  Cancer and Chemotherapy.  (1-8-9 Yaesu,
   Chuo-ku, Tokyo 103, Japan) V.1-    1974-  Volume(issue)/page/year:
   18,371,1991
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraarterial
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
REFERENCE :
   GTKRDX Gan to Kagaku Ryoho.  Cancer and Chemotherapy.  (1-8-9 Yaesu,
   Chuo-ku, Tokyo 103, Japan) V.1-    1974-  Volume(issue)/page/year:
   18,371,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4930 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   49,4098,1989
 
                            *** END OF RECORD ***