*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9425600
CHEMICAL NAME           : 5,12-Naphthacenedione,
                          7,8,9,10-tetrahydro-8-(hydroxyacetyl)-1-methoxy-10-((
                          2,3,6-trideoxy-
                          3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-6,8
                          ,11-trihydroxy-, (8S-cis)-
CAS REGISTRY NUMBER     : 70222-95-6
OTHER CAS REGISTRY NOS. : 99759-64-5
                          94730-44-6
                          83310-79-6
BEILSTEIN REFERENCE NO. : 1416604
LAST UPDATED            : 199706
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C29-H33-N-O11
MOLECULAR WEIGHT        : 571.63
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * AD 280
   * N,N-Dimethyladriamycin
   * N,N-Dimethyldoxorubicin
   * NSC-261 045
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 24 mg/kg/2W-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Blood - changes in leukocyte (WBC) count
   Related to Chronic Data - death
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 1,267,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 mg/kg/3W-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Cardiac - other changes
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 1,267,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22 mg/kg/11W-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Related to Chronic Data - death
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 1,267,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 20 ug/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,5599,1984
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,5599,1984
 
                            *** END OF RECORD ***