*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : QI9425600 CHEMICAL NAME : 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-8-(hydroxyacetyl)-1-methoxy-10-(( 2,3,6-trideoxy- 3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-6,8 ,11-trihydroxy-, (8S-cis)- CAS REGISTRY NUMBER : 70222-95-6 OTHER CAS REGISTRY NOS. : 99759-64-5 94730-44-6 83310-79-6 BEILSTEIN REFERENCE NO. : 1416604 LAST UPDATED : 199706 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C29-H33-N-O11 MOLECULAR WEIGHT : 571.63 COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * AD 280 * N,N-Dimethyladriamycin * N,N-Dimethyldoxorubicin * NSC-261 045 *** HEALTH HAZARD DATA *** ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 24 mg/kg/2W-I TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects Blood - changes in leukocyte (WBC) count Related to Chronic Data - death REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 1,267,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15 mg/kg/3W-I TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects Cardiac - other changes REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 1,267,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 22 mg/kg/11W-I TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects Related to Chronic Data - death REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 1,267,1978 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 20 ug/plate REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,5599,1984 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 1 mg/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,5599,1984 *** END OF RECORD ***