*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QI9425750
CHEMICAL NAME           : 5,12-Naphthacenedione,
                          7,8,9,10-tetrahydro-8-(hydroacetyl)-1-methoxy-10-((2,
                          3,6-trideoxy-3-
                          (((dimethylamino)methylene)amino)-alpha-L-lyxo-hexopy
                          ranosyl)oxy)-6,8,11-t rideoxy-, (8S-cis)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 119943-52-1
LAST UPDATED            : 199206
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C30-H34-N2-O11.Cl-H
MOLECULAR WEIGHT        : 635.12
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 3'-Desamino-3'-dimethylformamidinedoxorubicin hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Gastrointestinal - hypermotility, diarrhea
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   ANKHEW Antibiotiki i Khimioterapiya.  Antibiotics and Chemotherapy. (V/O Me
   zhdunarodnaya Kniga, 113095 Moskow, USSR)  V.33-    1988-
   Volume(issue)/page/year: 34,105,1989
 
                            *** END OF RECORD ***