*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : QJ0400000 CHEMICAL NAME : 1-Naphthalenamine, 1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-, (1S-cis)- CAS REGISTRY NUMBER : 79617-96-2 BEILSTEIN REFERENCE NO. : 5753709 LAST UPDATED : 199712 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C17-H17-Cl2-N MOLECULAR WEIGHT : 306.25 COMPOUND DESCRIPTOR : Drug Human SYNONYMS/TRADE NAMES : * Cp 51974 * Sertraline * (1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalen amine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 63 mg/kg/10W-I TOXIC EFFECTS : Blood - tumors REFERENCE : AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 153,443,1996 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 70 mg/kg/7W-I TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 153,732,1996 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 28 mg/kg/4W-I TOXIC EFFECTS : Blood - agranulocytosis REFERENCE : PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 72,446,1996 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 10500 ug/kg/3W-I TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Endocrine - antidiuresis Nutritional and Gross Metabolic - other changes REFERENCE : AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 123,811,1995 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 5714 ug/kg/9D-I TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement REFERENCE : JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978- Volume(issue)/page/year: 55,316,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 3571 mg/kg/5D-I TOXIC EFFECTS : Endocrine - antidiuresis Nutritional and Gross Metabolic - other changes REFERENCE : AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 152,809,1995 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 6 mg/kg/4D-I TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Endocrine - antidiuresis Nutritional and Gross Metabolic - other changes REFERENCE : AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 152,809,1995 *** END OF RECORD ***