*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BA6330000
CHEMICAL NAME           : Allylamine, N,N-diethyl-3,3-di-2-thienyl-1-methyl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 132-19-4
LAST UPDATED            : 199009
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C16-H21-N-S2.Cl-H
MOLECULAR WEIGHT        : 327.96
WISWESSER LINE NOTATION : T5SJ BYU1Y1&N2&2&- BT5SJ &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 3-Buten-2-amine, N,N-diethyl-4,4-di-2-thienyl-, hydrochloride
   * 191C49 hydrochloride
   * Diethibutin hydrochloride
   * 3-Diethylamino-1,1-di(2'-thienyl)but-1-ene hydrochloride
   * N,N-Diethyl-1-methyl-3,3-di-2-thienylallylamine hydrochloride
   * Diethylthiambutene hydrochloride
   * NIH-4185 hydrochloride
   * Themalon hydrochloride
   * Thiambutene hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 8,2,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 81 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - excitement
   Behavioral - analgesia
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 8,2,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - excitement
   Behavioral - analgesia
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 8,2,1953
 
                            *** END OF RECORD ***