*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : BD0525000
CHEMICAL NAME : Aluminum chloride
CAS REGISTRY NUMBER : 7446-70-0
LAST UPDATED : 199712
DATA ITEMS CITED : 38
MOLECULAR FORMULA : Al-Cl3
MOLECULAR WEIGHT : 133.33
WISWESSER LINE NOTATION : AL G3
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Alluminio(cloruro di)
* Aluminiumchlorid
* Aluminum chloride (1:3)
* Aluminum trichloride
* Chlorure d'aluminium
* Pearsall
* Trichloroaluminum
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3450 mg/kg
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Gastrointestinal - other changes
Kidney, Ureter, Bladder - hematuria
REFERENCE :
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
Volume(issue)/page/year: 36(1-4),10,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 315 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 43(4),12,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 30(4),16,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 390 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 43(4),12,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides
and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
Washington, DC 20460) History unknown. Volume(issue)/page/year:
8EHQ-0191-1109
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9380 mg/kg/52D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in phosphorus
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year:
23,305,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2307 mg/kg/26W-I
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 30,47,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 gm/kg/48W-C
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Behavioral - alteration of operant conditioning
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
4,403,1982
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 99 mg/kg/5D-I
TOXIC EFFECTS :
Musculoskeletal - osteomalacia
REFERENCE :
KDYIA5 Kidney International. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secaucus Secaucus, NJ 07094) V.1- 1972-
Volume(issue)/page/year: 23,327,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 15 mg/kg/3D-I
TOXIC EFFECTS :
Blood - changes in erythrocyte (RBC) count
Blood - changes in leukocyte (WBC) count
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology
and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY
10591) V.74- 1983- Volume(issue)/page/year: 105,73,1993
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8421 mg/kg/40D-C
TOXIC EFFECTS :
Behavioral - food intake (animal)
Nutritional and Gross Metabolic - changes in metals, not otherwise specified
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year:
23,305,1966
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 11512 mg/kg
SEX/DURATION : female 8-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
8,115,1986
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 5723 mg/kg
SEX/DURATION : female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other neonatal measures or effects
Reproductive - Effects on Newborn - behavioral
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 40,21,1989
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 900 mg/kg
SEX/DURATION : female 15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - behavioral
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological
Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 18,43,1993
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 375 mg/kg
SEX/DURATION : female 9-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
REFERENCE :
ANANAU Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176,
Jena DDR-6900, Ger. Dem. Rep.) V.1- 1886- Volume(issue)/page/year:
138,365,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 500 mg/kg
SEX/DURATION : female 14-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
ANANAU Anatomischer Anzeiger. (VEB Gustav Fischer Verlag, Postfach 176,
Jena DDR-6900, Ger. Dem. Rep.) V.1- 1886- Volume(issue)/page/year:
138,365,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 425 mg/kg
SEX/DURATION : multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
BJIMAG British Journal of Industrial Medicine. (British Medical Journal,
Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year:
23,305,1966
** MUTATION DATA **
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Ascites tumor
DOSE/DURATION : 500 umol/L
REFERENCE :
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD
21202) V.1- 1905- Volume(issue)/page/year: 261,3370,1986
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 444 mg/kg
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in
Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta
700 019, India) V.1- 1958- Volume(issue)/page/year: 15,180,1972
*** REVIEWS ***
ACGIH TLV-TWA 2 mg(Al)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 2 mg(Al)/m3 JAN 1993
OEL-BELGIUM:TWA 2 mg(Al)/m3 JAN 1993
OEL-DENMARK:TWA 2 mg(Al)/m3 JAN 1993
OEL-FRANCE:TWA 2 mg(Al)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 2 mg(Al)/m3 JAN 1993
OEL-RUSSIA:TWA 2 mg(Al)/m3 JAN 1993
OEL-SWEDEN:TWA 2 mg(Al)/m3 JAN 1993
OEL-SWITZERLAND:TWA 2 mg(Al)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 2 mg(Al)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 04605
No. of Facilities: 3476 (estimated)
No. of Industries: 29
No. of Occupations: 34
No. of Employees: 17152 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 04605
No. of Facilities: 2230 (estimated)
No. of Industries: 32
No. of Occupations: 68
No. of Employees: 49913 (estimated)
No. of Female Employees: 17460 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-nonhuman bone
marrow
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; B subtilis rec
assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***